Clinical manifestations and prognosis of Wegener's granulomatosis.

reported. In contrast, we recently reported a case of WGin whomthe first clinical manifestation was acute renal failure due to periglomerular granulomatosis with crescentic glomerulonephritis and the late development of respiratory lesion. The case could be a "delayed variant" or limited form of WG localized in the kidney (1). Accordingly, the combination of organ involvement is not sufficient to conclude WG. WGhas been considered to be a pathological entity (2). The typical histopathological features of WGconsist of ® inflammation of the upper and lower respiratory tracts with necrosis and granuloma formation, © systemic necrotizing angiitis, and (3) focal granulomatous glomerulonephritis. Fauci et al (3)